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Clofarabine (CAS 123318-82-1)




Product specification

Formula: C10H11ClFN5O3
MW: 303.68
Purity: >99%
Appearance: White solid.
Solubility: 10 mM in water and to 100 mM in DMSO
Storage: +4˚C.
CAS Number: 123318-82-1
Synonyms: Clolar, Evoltra, 2-Chloro-9-(2-deoxy-2-fluoro-
β-D-arabinofuranosyl)-9H-purin-6-amine
Cat.number: VD-ESA-0006

Product Description

Clofarabine (CAS 123318-82-1) is a deoxycistidine kinase (dCK) substrate. Phosphorylated to form clofarabine triphosphate, which competes with dATP for DNA polymerase-α and -ε and potently inhibits ribonucleotide reductase (IC50 = 65 nM). Induces apoptosis by directly altering mitochondrial transmembrane potential. Demonstrates growth inhibition and cytotoxic activity in a variety of leukemias and solid tumors.



Product References
1.Parker et al (1991)  Cancer Res. 51 2386.
2.Carson et al (1992) Proc.Natl.Acad.Sci.USA 89 2970.
3.Bonate et al (2006)  Nat.Rev.Drug Discov. 5 855.