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2-Deoxy-D-glucose (CAS 154-17-6)

Product specification

Formula: C6H12O5
MW: 164.16
Purity: >95%
Appearance: White solid.
Solubility: 100 mM in water and to 100 mM in DMSO
Storage: +4˚C.
CAS Number: 154-17-6
Synonyms: 2-Deoxy-D-glucose, 2-Deoxy-D-arabino-hexose
Cat.number: VD-ESA-0007

Product Description

2-Deoxy-D-glucose (CAS 154-17-6) is a on-metabolizable glucose analog. Inhibits phosphorylation of glucose by hexokinase; causes depletion of cellular ATP. Also inhibits phosphoglucose isomerase (PGI) competitively. Causes cell cycle inhibition and cell death in in vitro models of hypoxia; blocks tumor cell growth in animal models. Also shown to induce the unfolded protein response (UPR).

Product References
1. Maher et al (2004) Cancer Chemother.Pharmacol. 53 116.
2. Kang and Hwang (2006) Life Sci. 78 1392.
3. Ralser et al (2008) Proc.Natl.Acad.Sci.USA 105 17807.