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BAY 41-2272 (CAS 256376-24-6)




Product specification

Formula: C20H17FN6
MW: 360.41
Purity: >=98%
Appearance: White solid.
Solubility: 100 mM in DMSO.
Storage: +4˚C.
CAS Number: 256376-24-6
Synonyms: BAY 41-2272, Riociguat
Cat.number: VD-ESA-0016

Product Description

BAY 41-2272 (CAS 256376-24-6) is an activator of soluble guanylyl cyclase (sGC); acts at a nitric oxide (NO)-independent regulatory site in the sGC α1 subunit. Inhibits platelet aggregation (IC50 = 36 nM) and phenylephrine-induced contractions of rabbit aorta (IC50 = 0.30 μM). Also reduces vascular smooth muscle growth through cAMP- and cGMP-dependent PKA and PKG pathways.



Product References
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2. Stasch et al (2010)  Nature 410 212.
3. Joshi et al (2011)  J.Pharmacol.Exp.Ther. 339 394.