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NKH 477 (CAS 138605-00-2)




Product specification

Formula: C27H43NO8.HCl
MW: 546.1
Purity: >98%
Appearance: White solid.
Solubility: 40 mM in water.
Storage: +4°C.
CAS Number: 138605-00-2
Synonyms: NKH 477, Colforsin dapropate hydrochloride
Cat.number: VD-ESA-0021

Product Description

NKH 477 (CAS 138605-00-2) is a water-soluble analog of Forskolin (Cat.No. VD-ESA-0019) that is a potent activator of adenylyl cyclase; shows some selectivity for cardiac (type V) adenylyl cyclase. Stimulates bronchodilation (EC50 = 32.6 nM) and is an orally active potent positive chronotrope and hypotensive agent in vivo.



Product References
1. Hosono et al (1992) J.Cardiovasc.Pharmacol. 19 625.
2. Satake et al (1998)  Br.J.Pharmacol. 123 753.
3. Toya et al (1998)  J.Mol.Cell.Cardiol. 30 97.