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Phorbol 12,13-dibutyrate (CAS 75567-37-2)

Product specification

Formula: C28H40O8
MW: 504.61
Purity: >98%
Appearance: White lyophilised solid
Solubility: 50 mM in DMSO
Storage: -20°C.
CAS Number: 37558-16-0
Synonyms: Phorbol 12,13-dibutyrate
Cat.number: VD-ESA-0024

Product Description

Phorbol 12,13-dibutyrate (CAS 37558-16-0) is a protein kinase C activator. Induces contraction of vascular smooth muscle and inhibits MLC phosphatase (MLCP) in vascular smooth muscle. Activity does not alter intracellular Ca2+ concentration. Also inhibits the activity of Na+,K+ ATPase in OK cells.

Product References
1. Middleton et al (1993) J.Biol.Chem. 268 15958.
2. Hori et al (1999)  J.Neurosci. 19 7262.
3. Sakai et al (2010) J.Smooth Muscle Res. 46 259.