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VD-ESA-0031-0010-10mg 70 USD
VD-ESA-0031-0050-50mg 300 USD

ZLN 024 hydrochloride




Product specification

Formula: C13H13BrN2OS.HCl
MW: 361.69
Purity: >99%
Appearance: White solid.
Solubility: 100 mM in DMSO.
Storage: +4˚C.
CAS Number: N/A
Synonyms: ZLN 024 hydrochloride
Cat.number: VD-ESA-0031

Product Description

ZLN 024 hydrochloride is an allosteric AMP-activated protein kinase (AMPK) activator; allosterically stimulates active AMPK heterotrimers, increasing the activity of α1β1γ1 by 1.5-fold and α2β1γ1 by 1.7-fold (EC50 values are 0.42 and 0.95 μM, respectively). Inhibits dephosphorylation of AMPK Thr-172 by PP2Cα. Stimulates glucose uptake and fatty acid oxidation without increasing the ADP/ATP ratio. Also decreases fatty acid synthesis and glucose output in primary hepatocytes. Improves glucose tolerance and decreases cholesterol content in db/db mice.



Product References
1. Li et al (2013) Toxicol.Appl.Pharmacol. 273 325.
2. Zhang et al (2013) PLoS One 8 e72092. PMID: 23977216.