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DC 260126 (CAS 346692-04-4)

Product specification

Formula: C16H18FNO2S
MW: 307.38
Purity: >98%
Appearance: White solid.
Solubility: 100 mM in DMSO and to 100 mM in ethanol
Storage: -20°C.
CAS Number: 346692-04-4
Synonyms: DC260126
Cat.number: VD-TMR-0007

Product Description

DC 260126 (CAS 346692-04-4) is a free fatty acid receptor 1 (FFA1/GPR40) antagonist. Inhibits FFA-induced increases in intracellular Ca2+ levels and suppresses palmitic acid potentiated glucose-stimulated insulin secretion in Min6 pancreatic β cells in vitro. Decreases serum insulin levels, improves insulin sensitivity and reduces the number of apoptotic pancreatic β cells in obese diabetic (db/db) rats.

Product References
1. Hu et al (2009) Biochem.Biophys.Res.Comm. 390 557.
2. Zhang et al (2010) Biomed.Pharmacother. 64 647.
3. Sun et al (2013) PLoS ONE 8 e66744.