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Eplivanserin hemifumarate (CAS 130580-02-8)




Product specification

Formula: C19H21FN2O2.0.5C4H4O4
MW: 386.42
Purity: >98%
Appearance: White crystalline solid
Solubility: 50 mM in DMSO
Storage: +4˚C.
CAS Number: 130580-02-8
Synonyms: SR-46349 hemifumarate, SR-46349B
Cat.number: VD-TMR-0008

Product Description

Eplivanserin hemifumarate (CAS 130580-02-8) is a potent and selective 5-HT2A antagonist (IC50 values are 5.8 and 120 and >100 nM for 5-HT2A, 5-HT2B and 5-HT2C, respectively). Attenuates cocaine-induced hyperactivity. Increases dopamine (DA) release in rat medial prefrontal cortex (mPFC); potentiates haloperidol-induced DA release in the mPFC and nucleus accumbens.



Product References
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2. Filip et al (2004) J.Pharmacol.Exp.Ther. 310 1246.
3. Yadav et al (2011) J.Pharmacol.Exp.Ther. 339 99.