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Eplivanserin hemifumarate (CAS 130580-02-8)

Product specification

Formula: C19H21FN2O2.0.5C4H4O4
MW: 386.42
Purity: >98%
Appearance: White crystalline solid
Solubility: 50 mM in DMSO
Storage: +4˚C.
CAS Number: 130580-02-8
Synonyms: SR-46349 hemifumarate, SR-46349B
Cat.number: VD-TMR-0008

Product Description

Eplivanserin hemifumarate (CAS 130580-02-8) is a potent and selective 5-HT2A antagonist (IC50 values are 5.8 and 120 and >100 nM for 5-HT2A, 5-HT2B and 5-HT2C, respectively). Attenuates cocaine-induced hyperactivity. Increases dopamine (DA) release in rat medial prefrontal cortex (mPFC); potentiates haloperidol-induced DA release in the mPFC and nucleus accumbens.

Product References
1. Bonaccorso et al (2002) 27 430.
2. Filip et al (2004) J.Pharmacol.Exp.Ther. 310 1246.
3. Yadav et al (2011) J.Pharmacol.Exp.Ther. 339 99.