EPPTB (CAS 1110781-88-8)

EPPTB (CAS 1110781-88-8) is a trace amine 1 (TA₁) receptor antagonist/inverse agonist; exhibits a higher potency at the mouse TA₁ receptor than the rat and human TA₁ receptors (IC₅₀ values are 27.5, 4539 and 7487 nM, respectively). Blocks the TA₁ receptor-mediated activation of an inwardly rectifying K⁺ current, which increases the firing frequency of dopamine (DA) neurons in the ventral tegmental area. Increases DA potency at the D₂ receptor. Also displays inverse agonism, reducing basal cAMP levels in vitro (IC₅₀ = 19 nM).