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EPPTB (CAS 1110781-88-8)




Product specification

Formula: C20H21F3N2O2
MW: 378.39
Purity: >99%
Appearance: White solid.
Solubility: 100 mM in DMSO and to 100 mM in ethanol
Storage: +4˚C
CAS Number: 1110781-88-8
Synonyms:
Cat.number: VD-TMR-0009

Product Description

EPPTB (CAS 1110781-88-8) is a trace amine 1 (TA1) receptor antagonist/inverse agonist; exhibits a higher potency at the mouse TA1 receptor than the rat and human TA1 receptors (IC50 values are 27.5, 4539 and 7487 nM, respectively). Blocks the TA1 receptor-mediated activation of an inwardly rectifying K+ current, which increases the firing frequency of dopamine (DA) neurons in the ventral tegmental area. Increases DA potency at the D2 receptor. Also displays inverse agonism, reducing basal cAMP levels in vitro (IC50 = 19 nM).



Product References
1. Bradaia et al (2009) Proc.Natl.Acad.Sci.U.S.A. 106 20081.