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MK 0677 (CAS 159752-10-0)




Product specification

Formula: C27H36N4O5S.CH3SO3H
MW: 624.77
Purity: >98%
Appearance: Off-white solid.
Solubility: 50 mM in water and to 100 mM in DMSO
Storage: +4˚C.
CAS Number: 159752-10-0
Synonyms: Ibutamoren mesylate, L-163,191
Cat.number: VD-TMR-0012

Product Description

MK 0677 (CAS 159752-10-0) is a high affinity ghrelin receptor agonist (pKi = 8.14). Growth hormone (GH) secretagog; stimulates GH release from rat pituitary cells in vitro (EC50 = 1.3 nM) and enhances GH plasma levels in vivo. Also attenuates isoproterenol-induced lipolysis in rat adipocytes in vitro. Orally bioavailable.



Product References
1. Patchett et al (1995) Proc.Natl.Acad.Sci.U.S.A. 92 7001.
2. Mucciolo et al (2004) Eur.J.Pharmacol. 498 27.
3. Bennett et al (2009) Mol.Pharmacol. 76 802.