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NIBR 189 (CAS 1599432-08-2)

Product specification

Formula: C21H21BrN2O3
MW: 429.31
Purity: >98%
Appearance: White solid
Solubility: 100 mM in DMSO.
Storage: +4˚C.
CAS Number: 1599432-08-2
Synonyms: NIBR189
Cat.number: VD-TMR-0014

Product Description

NIBR 189 (CAS 1599432-08-2) is a potent and selective EBI2 (GPR183) receptor antagonist (IC50 values are 11 and 15 nM for human and mouse EBI2 receptors respectively). Exhibits selectivity for EBI2 over a panel of other receptors, enzymes and transporters. Blocks oxysterol-induced migration of U937 monocyte cells. Orally bioavailable.

Product References
1. Gessier et al (2014) J.Med.Chem. 57 3358.