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Leflunomide 3-Isomer (CAS 61643-23-0)

Product specification

Formula: C12H9F3N2O2
MW: 270.21
Purity: ≥95%
Appearance: Fine yellowish-white powder
Storage: +4˚C
CAS Number: 61643-23-0
Synonyms: 5-Methyl-N-[3-(trifluoromethyl)
Cat.number: VD-HA-0112

Product Description

Leflunomide 3-Isomer (CAS 61643-23-0) is a Leflunomide (VD-HA-0262) analogue, with potential antiinflammatory and anti-viral activity. Immunosuppressant agent. In vitro the active metabolite A77 1726 inhibits dihydroorotate dehydrogenase (Ki = 2.7 μM) and de novo pyrimidine synthesis in T-cells; blocks lymphocyte cell cycle progression and proliferation. In vivo reduces inflammation in several animal models of autoimmune disease, arthritis, asthma and graft rejection.

Product References
1. Chong, A.S., et al. 1993. Transplant. Proc. 25: 747-749.
2. Chong, A.S., et al. 1993. Transplantation. 55: 1361-1366.  
3. Ju, D.W., et al. 1994. Yao Xue Xue Bao. 29: 90-94.