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Leflunomide 3-Isomer (CAS 61643-23-0)




Product specification

Formula: C12H9F3N2O2
MW: 270.21
Purity: ≥95%
Appearance: Fine yellowish-white powder
Solubility:
Storage: +4˚C
CAS Number: 61643-23-0
Synonyms: 5-Methyl-N-[3-(trifluoromethyl)
phenyl]-4-isoxazolecarboxamide
Cat.number: VD-HA-0112

Product Description

Leflunomide 3-Isomer (CAS 61643-23-0) is a Leflunomide (VD-HA-0262) analogue, with potential antiinflammatory and anti-viral activity. Immunosuppressant agent. In vitro the active metabolite A77 1726 inhibits dihydroorotate dehydrogenase (Ki = 2.7 μM) and de novo pyrimidine synthesis in T-cells; blocks lymphocyte cell cycle progression and proliferation. In vivo reduces inflammation in several animal models of autoimmune disease, arthritis, asthma and graft rejection.



Product References
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2. Chong, A.S., et al. 1993. Transplantation. 55: 1361-1366.  
3. Ju, D.W., et al. 1994. Yao Xue Xue Bao. 29: 90-94.