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VD-AIH-0124-0005-20mg 60 USD
VD-AIH-0124-0050-200mg 450 USD

Necrostatin-1




Product specification

Formula: C13H13N3OS
MW: 259.3
Purity: ≥99% by HPLC.
Appearance: Yellow solid
Solubility: DMSO or MeOH
Storage: +2°C to +8°C. Protect from light.
CAS Number: 4311-88-0
Synonyms: Nec-1; Necroptotic Inhibitor
Cat.number: VD-AIH-0124

Product Description

A cell-permeable, potent, and selective blocker of necroptosis (EC50 = 494 nM in FADD-deficient Jurkat cells treated with TNF-α), a nonapoptotic necrotic cell death pathway mediated by death-domain receptors (DRs) that offers neuroprotection in a murine model of ischemic brain injury. Exhibits no effect on DR-induced apoptosis. Nec-1 target appears to be a critical common necroptotic step upstream of execution events and downstream of DRs.  ATP-competitive death domain receptor-associated adaptor kinase (RIP1) allosteric inhibitor (EC50 = 182 nM). Blocks non-apoptotic cell death via inhibition of a specific cellular pathway, necroptosis, which leads to necrosis (EC50 = 494 nM). Reduces ischemic brain injury in a mouse model of stroke.



Product References
1.Degterev, A., et al. 2008. Nat. Chem. Biol. in press.
2.Degterev, A., et al. 2005. Nat. Chem. Biol. 1, 112.



Certificate of Analysis (CoA)