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VD-Ant-0259-0050-50mg 110 USD
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Azaserine (CAS 115-02-6)

Product specification

Formula: C5H7N3O4
MW: 173,13
Purity: ≥98% (TLC)
Appearance: White/light yellow/green crystalline powder
Solubility: H2O, MeOH
Storage: 2-8°C. Protect from light.
CAS Number: 115-02-6
Synonyms: NSC-742; L-azaserine; AZS
Cat.number: VD-Ant-0259

Product Description

Azaserine (CAS 115-02-6) is an antibiotic and antifungal; it may also act as a tumor inducer. It is a structural analog of glutamine and competes with glutamine in binding to enzymes involved in purine biosynthesis. Azaserine inhibits purine biosynthesis by covalently reacting with cysteine residues in the enzyme active sites, such as in formylglycinamide ribonucleotide amidotransferase and PRPP amidotransferase. Azaserine can induce DNA damage via the formation of carboxymethylated bases and O6-methylguanine. Secretion of exo-1,3-β-glucanase and germ-tube formation of Candida albicans were inhibited by azaserine.

Product References
1. G.B. Segel et al. J. Biol. Chem. 264, 16399, (1989).
2. A. Honda et al. Biochem. J. 261, 627, (1989).