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Ritonavir (CAS 155213-67-5)




Product specification

Formula: C37H48N6O5S2
MW: 720.95
Purity: ≥98%
Appearance: White to off-white powder
Solubility: Methanol.
Storage: -20°C.Protect from moisture.
CAS Number: 155213-67-5
Synonyms: Norvir, Abbott 84538, ABT-538
Cat.number: VD-HA-0266

Product Description

Ritonavir (CAS 155213-67-5 is a protease inhibitor with activity against Human Immunodeficiency Virus Type 1 (HIV-1). Protease inhibitors block the part of HIV called protease. HIV-1 protease is an enzyme required for the proteolytic cleavage of the viral polyprotein precursors into the individual functional proteins found in infectious HIV-1. Ritonavir binds to the protease active site and inhibits the activity of the enzyme. This inhibition prevents cleavage of the viral polyproteins resulting in the formation of immature non-infectious viral particles. Protease inhibitors are almost always used in combination with at least two other anti-HIV drugs. Ritonavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles. Indicated in combination with other antiretroviral agents for the treatment of HIV-infection.



Product References
1.Daluge, S., et al.: Antimicrob. Agents Chemother., 38, 1590 (1994).
2.Ammaranond, P., et al.: J. Clin. Virol., 26, 153 (2003).
3.Miller, J., et al.: Bioorg. Med. Chem. Lett., 16, 1788(2006).



Certificate of Analysis (CoA)