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VD-AIH-0275-0010-10mg 80 USD
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Apoptosis Inhibitor II, NS3694, (CAS 426834-38-0)




Product specification

Formula: C15H10ClF3N2O3
MW: 358.7
Purity: ≥95% by HPLC
Appearance: White solid
Solubility: DMSO
Storage: +2°C to +8°C
CAS Number: 426834-38-0
Synonyms: 4-chloro-2-(3-(3-(trifluoromethyl)phenyl)ureido)benzoic acid
Cat.number: VD-AIH-0275

Product Description

Apoptosis Inhibitor II, NS3694, (CAS 426834-38-0) is a cell-permeable diarylurea compound that specifically prevents the active ~700-kDa apoptosome complex formation triggered by cytochrome c release, thus blocking apoptosome-mediated caspase activation and cell death (50 µM completely blocks TNF-α-induced death in MCF-casp3 cells). Unlike M50054, NS3694 exhibits no effect on apoptosome-independent caspase activation and cell death induced by FasL. Inhibits neither cytochrome c release nor the enzymatic activity of caspases. 



Product References
1.Lademann, U., et al. 2003. Mol. Cell. Biol. 23, 7829.