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L-C-Propargylglycine (CAS 23235-01-0)




Product specification

Formula: C5H7NO2
MW: 113.12
Purity: >=99.0% (TLC).
Appearance: White powder
Solubility: DMSO.
Storage: +2°C to +8°C. Protect from light.
CAS Number: 23235-01-0
Synonyms: H-Pra-OH
Cat.number: VD-Ant-0341

Product Description

L-C-Propargylglycine (CAS 23235-01-0) is an unusual amino acid which is produced by microorganisms, it has been detected in the poisonous mushroom Amanita abrupta. Precursor for tritiated norleucine which may be introduced synthetically into peptides. For a review of the synthetic applications of aliphatic unsaturated α-amino acids see Kaiser et al. Pra has been used in click chemistry. Thus, cyclization of Pra-containing peptides via triazole formation with a lateral azide group proceeds smoothly in the presence of CuBr.



Product References
1.P.Scannell et al., J. Antibiot., 24, 239 (1971).
2.O.Leukart et al., Helv. Chim. Acta, 59, 2181 (1976).
3.Y.Yamaura et al., Toxicology, 38, 161 (1986).
4.J.Kaiser et al., Org. Biomol. Chem., 3, 3435 (2005).
5.R.A.Turner et al., Org. Lett., 9, 5011 (2007).