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VD-Ant-0343-0025-25g 180 USD
VD-Ant-0343-0100-100g 520 USD


Product specification

Formula: C11H14N3O5P
MW: 299.22
Purity: ≥95%
Appearance: White to yellow powder
Storage: Longterm storage temperature: -20 ± 5 °C
CAS Number: 165534-43-0
Synonyms: 3-(Diethoxyphosphoryloxy)-1,2,3-benzotriazin-4(3H)-one;
Chemical name: diethyl 4-oxobenzo[d]
[1,2,3]triazin-3(4H)-yl phosphate
Cat.number: VD-Ant-0343

Product Description

This new crystalline phosphate reagent mediates amide bond formation with a remarkable resistance to racemization. Thus, DEPBT is an excellent activation reagent for coupling the racemization-prone Fmoc-His(Trt)-OH. The use of DEPBT permitted the total synthesis of the antiviral peptide antibiotic feglymycin, which contains a high proportion of ring-substituted phenylglycines.

Product References
C.-X.Fan et al., Synth. Commun., 26, 1455 (1996). H.Li et al., Org. Lett., 1, 91 (1999). M.Mergler et al., Innovation and Perspectives in Solid Phase Synthesis and Combinatorial Libraries, 7th International Symposium, Southampton, p. 235, R.Epton, ed., Mayflower Worldwide, (2002). F.Dettmer et al., Angew. Chem. Int. Ed. Engl., 48, 1856 (2009).