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VD-OEIA-0025-0005-5mg 60 USD
VD-OEIA-0025-0050-50mg 550 USD

Histone Deacetylase Inhibitor II

Product specification

Formula: C10H10N2O4
MW: 222.2
Purity: ≥95%
Appearance: Off-white solid
Solubility: DMSO
Storage: -20°C. Protect from light.
CAS Number: 174664-65-4
Synonyms: m-Carboxy Cinnamic Acid bis-Hydroxamide, CBHA
Cat.number: VD-OEIA-0025

Product Description

A cell-permeable second generation hybrid polar agent that acts as a histone deacetylase (HDAC) inhibitor. The HDAC inhibition is believed to arise as a result of the binding of the hydroxamic moiety to the active site zinc. Shown to be a potent inducer of transformed cell growth arrest and terminal differentiation (~4 M). Induces apoptosis and the CD95/CD95-Ligand expression in human neuroblastoma.

Product References
1.Coffey, D.C., et al. 2001. Cancer Res. 61, 3591.
2.Coffey, D.C., et al. 2000. Pediatr. Oncol. 35, 577.
3.Marks, P.A., et al. 2000. J. Natl. Cancer Inst. 92, 1210.
4.Glick, R.D., et al. 1999. Cancer Res. 59, 4392.