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Exo1 (CAS 75541-83-2)




Product specification

Formula: C15H12FNO3
MW: 273.3
Purity: ≥95%
Appearance: White solid
Solubility: DMSO, DMF, MeOH or EtOH
Storage: +2°C to +8°C. Protect from light.
CAS Number: 75541-83-2
Synonyms: 2-(4-Fluorobenzoylamino)methylbenzoate;
2-(4-Fluorobenzoylamino)benzoic acid methyl ester
Cat.number: VD-NP-0004

Product Description

Exo1 (CAS 75541-83-2) is a cell-permeable methyl anthranilate analog that reversibly inhibits vesicular traffic from ER to Golgi in mammalian cells (IC50 = 20 µM in BSC1 cells) by inducing tubulation and collapsing of the Golgi membrane and redirecting the traffic back to ER. Acts as a potent and selective modifier of Golgi ARF1 GTPase activity. Unlike another membrane traffic inhibitor Brefeldin A , its effect seems to be limited to Golgi, as no effect can be detected on endocytic organelles, such as endosomes and TGN (trans-Golgi network). Its inhibitory mechanism and target(s) appear to be quite different from those of BFA and thus serves as a valuable alternative that complements BFA in membrane traffic studies. 



Product References

1. Feng. Y., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 6469.