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VD-NP-0006-0005-5mg 269 USD
VD-NP-0006-0050-50mg 2590 USD

Bcl-2 Inhibitor

Product specification

Formula: C16H16N2O4
MW: 300.3
Purity: ≥97% by TLC
Appearance: Green solid
Solubility: DMSO
Storage: -20°C. Protect from light. Packaged under inert gas.
CAS Number: 383860-03-5
Synonyms: 2,9-Dimethoxy-11,12-dihydrodibenzo[c,g]
[1,2]-diazocine 5,6-dioxide (A) and
5,5′-Dimethoxy-2,2′-dinitrosobenzyl (B)
Cat.number: VD-NP-0006

Product Description

Contains mixture of two tautomers (A and B). A potent, cell-permeable, Bcl-2 inhibitor that competes with Bak BH3 peptide for binding to Bcl-2 and Bcl-xL in vitro (IC50 = 10 µM and 7 µM, respectively). Reduces cell viability and growth in the HL-60 cell line with high Bcl-2 expression (IC50 = 4 µM). Also induces apoptosis in a dose-dependent manner in cancer cells exhibiting high Bcl-2 expression with little effect on cancer cells with low Bcl-2 expression.

Product References

Enyedy, I.J., et al. 2001. J. Med. Chem. 44, 4313.