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PPM1D Phosphatase Inhibitor (CAS 1087-07-6)




Product specification

Formula: C15H12OS2
MW: 272.4
Purity: ≥97%
Appearance: Yellow solid
Solubility: DMSO
Storage: +2°C to +8°C. Protect from light
CAS Number: 1087-07-6
Synonyms: 2,5-bis-(2-Thienylidene)cyclopentanone; CCT007093;
(2E,5E)-2,5-bis(thiophen-2-ylmethylene)cyclopentanone
Cat.number: VD-NP-0010

Product Description

PPM1D Phosphatase Inhibitor (CAS 1087-07-6) is a cell-permeable thienylidene cyclopentanone compound that inhibits the PPM ser/thr phosphatase member PPM1D/PP2Cδ/WIP1 (IC50 = 8.4 µM), while exhibiting little activity against PPM1A even at concentrations as high as 100 µM. Selectively inhibits the growth of high PPM1D-expressing tumor cells (SF50 = 0.13, 0.17 & 0.48 µM for MCF-3B, KPL-1, & MCF-7, respectively, in colony formation assays), but not low PPM1D-expressing tumor cells (SF50 = 34 & >50 µM for 239T & HeLa, respectively). Inhibition of p38 MAP kinase activity by SB203580 is shown to fully prevent PPM1D inhibitor-induced growth arrest of MCF-7 cells.



Product References
1. Rayter, S., et al., Oncogene 27(8), 1036-44, (2008).
2. Pärssinen, J., et al., Cancer Gene Ther. 182(1), 33-9, (2008).