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VD-NP-0018-0010-10mg 55 USD
VD-NP-0018-0100-100mg 450 USD

AG 1288




Product specification

Formula: C10H5N3O4
MW: 231.16
Purity: ≥95% by HPLC
Appearance: Orange-yellow solid
Solubility: DMSO
Storage: -20°C. Protect from light.
CAS Number: 116313-73-6
Synonyms: α-Cyano-(3,4-dihydroxy-5-nitro)cinnamonitrile;
2-(3,4-dihydroxy-5-nitrobenzylidene)malononitrile
Cat.number: VD-NP-0018

Product Description

A cell-permeable compound shown to actively block TNF-α induced cytotoxicity. Has properties similar to AG 126. Blocks the glucocorticoid-induced COX-2 activity in human amnion cells (IC50 = 21 µM).



Product References
Jaleel, M., et al. 2004. Biochemistry 43, 8247. Zakar, T., et al. 1999. Can. J. Physiol. Pharmacol. 77, 138. Novogrodsky, A., et al. 1994. Science 264, 1319.