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VD-NP-0023-0005-5mg 150 USD
VD-NP-0023-0025-25mg 550 USD

Akt Inhibitor X

Product specification

Formula: C20H25ClN2O • HCl
MW: 381.34
Purity: ≥98%.
Appearance: White solid
Solubility: H2O
Storage: +2°C to +8°C. Protect from light. Hygroscopic.
CAS Number: 925681-41-0
Synonyms: 10-(4′-(N-diethylamino)butyl)-2-chlorophenoxazine, HCl
Cat.number: VD-NP-0023

Product Description

A cell-permeable, reversible, and selective inhibitor of the phosphorylation of Akt and its in vitro kinase activity (complete inhibition <5 µM) with minimal effect on PI 3-K, PDK1, or SGK1. Shown to suppress growth of Rh (rhabdomyosarcoma) cell lines (IC50 = 2-5 µM), inhibit IGF-I-stimulated nuclear translocation of Akt, and prevent phosphorylation of the downstream targets, mTOR, p70S6 kinase, and S6 ribosomal protein. Unlike Akti1/2, the mode of inhibition is not PH domain-dependent.

Product References
1.Thimmaiah, K.N., et al. 2005. J. Biol. Chem. 280, 31924.