Product # Price Quantity Add to cart
VD-NP-0028-0005-1mg 75 USD
VD-NP-0028-0010-10mg 550 USD

CA 074




Product specification

Formula: C18H29N3O6
MW: 383.4
Purity: >=98%
Appearance: Colorless or white solid.
Solubility: DMSO.
Storage: -20°C.Protect from light.
CAS Number: 134448-10-5
Synonyms: Cathepsin B Inhibitor III
Cat.number: VD-NP-0028

Product Description

An epoxysuccinyl peptide that acts as a potent, irreversible, and specific inhibitor of cathepsin B (IC50 = 2.24 nM for rat liver cathepsin B). Reduces ischemia-induced neuronal death. Exhibits lower membrane permeability when compared to CA-074 Me.  



Product References
1.Chan, V.J., et al. 1999. Biochem. J. 340, 113.
2.Tsuchiya, K., et al. 1999. Exp. Neurol. 155, 187.
3.Yamamoto, A., et al. 1997. J. Biochem. 121, 974.
4.Inubushi, T., et al. 1994. J. Biochem. 116, 282.
5.Murata, M., et al. 1991. FEBS Lett. 280, 307.