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Ac-DEVD-AFC (CAS 201608-14-2)

Product specification

Formula: C30H34F3N5O13
MW: 729.61
Purity: ≥90% (HPLC)
Appearance: White powder
Solubility: H2O: soluble1 mg/mL
Storage: −20°C
CAS Number: 201608-14-2
Synonyms: N-Acetyl-Asp-Glu-Val-Asp-7-amido-4-trifluoromethylcoumarin
Cat.number: VD-NP-0052

Product Description

Ac-DEVD-AFC (CAS 201608-14-2) is a fluorogenic substrate for caspase 3, a protease that is rapidly activated when cells are exposed to apoptotic conditions and that cleaves poly(ADP-ribose) polymerase. The 7-amido-4-trifluoromethylcoumarin derivative has better membrane permeability than the 7-amido-4-methylcoumarin derivative. 

Product References
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2. Marks, N., et al., J. Neurosci. Res. 52, 334-341, (1998). 
3. Martins, L.M., Blood 90, 4283, (1997).