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VD-NP-0064-0001-1mg 80 USD
VD-NP-0064-0005-5mg 312 USD


Product specification

Formula: C27H36FN5O7S
MW: 593.66
Purity: >=95%
Appearance: Off-white solid.
Solubility: DMSO.
Storage: Stock solutions in DMF or DMSO may be stored at -20 °C for up to one year.
CAS Number: Not available.
Synonyms: Biotin-Phe-Ala-Fluoromethylketone; Biotin-Phe-Ala-FMK
Cat.number: VD-NP-0064

Product Description

Biotin-Phe-Ala-Fluoromethyl Ketone is a cell permeable, biotinylated analog of the cathespin inhibitor Z-Phe-Ala-Fluoromethyl Ketone (Z-FA-FMK).Z-FA-FMK inhibits the cysteine proteases, Cathepsins B and L,1 but is not known to inhibit caspase enzymes.2,3 The concentration range for inhibition is 0.5 to 10 mM. Another similar analog, Biotin-Phe-Aladiazomethanealso inhibits Cathespin B. 4

Product References
1.Nisbet, A.J., and Billingsley, P.F., A comparative survey of the hydrolytic enzymes of ectoparasitic and free-living mites. Int J Parasitol., 30,19-27 (2000).
2.Gregoli, P.A., and Bondurant, M.C., Function of caspases in regulating apoptosis caused by erythropoietin deprivation in erythroid progenitors. J. Cell Physiol., 178, 133-43 (1999).
3.McColl, K.S. et al., Apoptosis induction by the glucocorticoid hormone dexamethasone and the calcium-ATPase inhibitor thapsigargin involves Bc1-2 regulated caspase activation. Mol. Cell Endocrinol., 139, 229-38 (1999).