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MG-132 (CAS 133407-82-6)

Product specification

Formula: C26H41N3O5
MW: 475.62
Purity: ≥98%
Appearance: Crystalline solid.
Solubility: DMSO, EtOH.
Storage: -20°C.
CAS Number: 133407-82-6
Synonyms: Carbobenzoxy-L-leucyl-L-leucyl-L-leucinal,
Cat.number: VD-AI-0034

Product Description

MG-132 (CAS 133407-82-6) is a potent, reversible, and cell-permeable proteasome inhibitor (Ki = 4 nM). Reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable strains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. Activates c-Jun N-terminal kinase (JNK1), which initiates apoptosis. Inhibits NF-B activation (IC50 = 3 M). Prevents -secretase cleavage. A 10 mM (1 mg/210 µl) solution of MG-132  in DMSO is also available.

Product References
1. Steinhilb, M.L., et al. 2001. J. Biol. Chem. 276, 4476.
2. Meriin, A.B., et al. 1998. J. Biol. Chem. 273, 6373.
3. Adams, J., and Stein, R. 1996. Ann. Rep. Med. Chem. 31, 279.
4 .Klafki, H.W., et al. 1996. J. Biol. Chem. 271, 2865.
5. Lee, D.H., and Goldberg, A.L., 1996. J. Biol. Chem. 271, 27280.

Certificate of Analysis (CoA)