Product # Price Quantity Add to cart
VD-AI-0280-0010-10mg 60 USD
VD-AI-0280-0100-100mg 550 USD


Product specification

Formula: C8H9NO4
MW: 183.16
Purity: ≥95% by HPLC
Appearance: White solid
Solubility: 100 mM in DMSO and to 100 mM in Ethanol
Storage: +4°C
CAS Number: 72835-26-8
Synonyms: 1-[(1-Oxopropoxy)methyl]-1H-pyrrole 2,5-dione
Cat.number: VD-AI-0280

Product Description

Restores wild-type conformation, function and DNA binding activity to mutant p53. Induces p53 transcriptional transactivation of p21, MDM2 and PUMA. Promotes tumor cell death by apoptosis in a mutant p53-dependent manner in vitro (IC50 = 10μM).

Product References
1.Bykov et al (2005) Reactivation of mutant p53 and induction of apoptosis in human tumor cells by maleimide analogs. J.Biol.Chem. 280 30384. Wiman (2006) Strategies for therapeutic targeting of the p53 pathway in cancer. Cell Death Differ. 13 921. Kumar et al (2007) p53 in breast cancer: mutation and countermeasures. Front.Biosci. 12 4168.