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VD-CHR-0006-0001-1g 170 USD
VD-CHR-0006-0010-10g 1550 USD

Hydroxytacrine maleate

Product specification

Formula: C13H14N2O·C4H4O4
MW: 330.3
Purity: >=98%
Appearance: White solid
Solubility: DMSO (25 mg/ml), Ethanol (10 mg/ml) and Water (5 mg/ml warm)
Storage: RT
CAS Number: 118909-22-1
Synonyms: 9-amino-1,2,3,4-tetrahydroacridin-1-ol maleate
Cat.number: VD-CHR-0006

Product Description

A cholinesterase inhibitor and a potential Alzheimer’s therapeutic of low toxicity. Exhibits biochemical and pharmacological profile similar to tacrine (THA) except that it is far less toxic and without measurable liver toxicity in humans. Tacrine is a parasympathomimetic and a centrally acting cholinesterase inhibitor (anticholinesterase). It was the first centrally-acting cholinesterase inhibitor approved for the treatment of Alzheimer's disease, and was marketed under the trade name Cognex. Major form of metabolism is in the liver via hydroxylation of benzylic carbon by CYP450. This forms the major metabolite 1-hydroxy-tacrine (velnacrine) which is still active.

Product References
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