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H-Cys(Trt)-OH (CAS 2799-07-7)




Product specification

Formula: C22H21NO2S
MW: 363.47
Purity: ≥98 % by TLC
Appearance: White to off-white powder
Solubility: 50 mM in DMSO
Storage: -20°C
CAS Number: 2799-07-7
Synonyms: NSC 83265; S-Trityl-L-cysteine
Cat.number: VD-CCR-0041

Product Description

H-Cys(Trt)-OH (CAS 2799-07-7) is a potent, cell-permeable, selective inhibitor of mitotic kinesin Eg5, a protein required for establishing and maintaining a bipolar spindle. Inhibits basal ATPase activity (IC50 = 1 mM) and microtubule-activated ATPase activity of Eg5 (IC50 = 140 nM). Induces mitotic arrest in HeLa cells with an IC50 of 700 nM. Displays antitumor activity. 



Product References
1. DeBonis et al (2004) Mol.Cancer Ther. 3 1079.
2. Brier et al (2004) Biochemistry 43 13072.