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VD-PI-0001-0005-5mg 90 USD
VD-PI-0001-0025-25mg 350 USD

Aminopeptidase N Inhibitor

Product specification

Formula: C17H10N2O8
MW: 370.3
Purity: ≥98%
Appearance: Off-white solid.
Solubility: DMSO
Storage: +2°C to +8°C. Protect from light.
CAS Number: Not available.
Synonyms: APN/CD13 Inhibitor
Cat.number: VD-PI-0001

Product Description

A dinitroflavone compound that acts as a selective, reversible, and competitive inhibitor of aminopeptidase N (APN/CD13; IC50=25 µM in U937 cells). Displays ~2-3 fold lower inhibition potency than Bestatin, but is not cytotoxic. Does not induce apoptosis, and only weakly affects the activities of MMP-9, angiotensin converting enzyme, neural endopeptidase, γ-glutamyl transpeptidase, DPPIV, and cathepsin-G even at concentrations as high as 1 mM.

Product References
1.Bauvois, B., et al. 2003. J. Med. Chem. 46, 3900.