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AG 490 (CAS 133550-30-8)




Product specification

Formula: C17H14N2O3
MW: 294.31
Purity: >=98%
Appearance: Pale yellow solid.
Solubility: 20 mM in EthOH and to 100 mM in DMSO.
Storage: -20°C. Protect from light.
CAS Number: 133550-30-8
Synonyms: Tyrphostin
Cat.number: VD-IS-0043

Product Description

AG 490 (CAS 133550-30-8) is a selective inhibitor of EGF receptor tyrosine kinase (IC50 values are 2 and 13.5 μM for EGFR and ErbB2 respectively). Inhibitor of JAK2, JAK3/STAT, JAK3/AP-1 and JAK3/MAPK pathways and potently inhibits cytokine-independent cell growth in vitro and tumor cell invasion in vivo.



Product References
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2.Meydan et al (1996),Nature 379 645.
3.Wang et al (1999),J.Immunol. 162 3897.