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VD-NP-0146-0010-10mg 140 USD
VD-NP-0146-0050-50mg 500 USD

P-Glycoprotein Inhibitor, C-4




Product specification

Formula: C23H18ClNO4
MW: 407.85
Purity: ≥95%
Appearance: Yellow solid
Solubility: DMSO
Storage: +2°C to +8°C
CAS Number: N/A
Synonyms: (E)-4-Chloro-N-(3-(3-(4-hydroxy-3-methoxy-
phenyl)acryloyl)phenyl)benzamide; C-4
Cat.number: VD-NP-0146

Product Description

P-Glycoprotein Inhibitor, C-4 is a cell-permeable cinnamoyl compound that reversibly inhibits P-gp (P-glycoprotein) efflux function. Also reverses the MDR (multidrug resistance) phenotype with no effect on P-gp expression. Significantly enhance Paclitaxel- and Vincristine- induced cytotoxicity as well as apoptosis in P-gp expressing KBV20C cells. Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.



Product References
1. Kim, Y.K., et al. 2007. Biochem. Biophys. Res. Commun. 355, 136.
2. Woo, H.B., et al. 2005. Bioorg. Med. Chem. Lett. 15, 3782.