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AG 213 (CAS 122520-86-9)




Product specification

Formula: C10H8N2O2S
MW: 220.25
Purity: ≥97%
Appearance: Yellow/orange solid
Solubility: 25 mM in EtOH, 100 mM in DMSO
Storage: +4°C
CAS Number: 122520-86-9
Synonyms: TyrphostinAG 213
Cat.number: VD-IS-0045

Product Description

AG 213 (CAS 122520-86-9) is an epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor (PDGFR) kinase inhibitor (IC50 values are 2.4 and 3 μM respectively). Stimulates microtubule polymerization and promotes neurite outgrowth > 17-fold over basal conditions in vitro. Also weakly inhibits protein kinase C (IC50 = 60 μM). 



Product References
1. Yaish et al 1988) Science 242 933.
2. Gazit et al (1989) J.Med.Chem. 32 2344.
3. Levitzki and Gazit (1995) Science 267 1782.
4. Plouffe et al (2006) Endocrinology 147 4646.