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AG 555 (CAS 133550-34-2)




Product specification

Formula: C19H18N2O3
MW: 322.36
Purity: ≥98% by HPLC
Appearance: Yellow solid
Solubility: 30 mM in DMSO, EtOH.
Storage: -20°C. Protect from light.
CAS Number: 133550-34-2
Synonyms: Tyrphostin AG 555
Cat.number: VD-IS-0047

Product Description

AG 555 (CAS 133550-34-2) is a potent epidermal growth factor receptor (EGFR) kinase inhibitor (IC50 = 0.7 μM) that displays 50-fold and >140-fold selectivity over ErbB2 and insulin receptor kinase respectively. Induce G1 growth arrest selectively in transformed cells (IC50 values are 6.4 and 9.4 μM in HPV16-immortalized and normal keratinocytes respectively). 



Product References
1. Gazit et al (1991) J.Med.Chem. 34 1896.
2. Levitzki and Gazit (1995) Science 267 1782.
3. Ben-Bassat et al (1999) J.Pharmacol.Exp.Ther. 290 1442.