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SU 6668 (CAS 252916-29-3)

Product specification

Formula: C18H18N2O8
MW: 310.35
Purity: >=99%
Appearance: Orange-red solid.
Solubility: 100 mM in 1eq. NaOH and to 100 mM in DMSO
Storage: RT. Keep cool and dry.
CAS Number: 252916-29-3
Synonyms: Orantinib
Cat.number: VD-AM-0053

Product Description

SU 6668 (CAS 252916-29-3) is a ATP-competitive PDGFR, VEGF and FGFR inhibitor (IC50 values are 0.06, 2.43, 3.04 and >100 μM at PDGFRβ, VEGFR2, FGFR1 and EGFR respectively). Inhibits proliferation of HUVEC and NIH3T3 cells in vitro (IC50 values are 0.41, 9.3 and 16.5 μM for VEGF, FGF and PDGF-stimulated growth respectively) and induces >75% growth inhibition against a broad range of tumor types in vivo. Exhibits antiangiogenic, anti-inflammatory, antimetastatic and proapototic activity and is orally active. 

Product References
1.Sun et al (1999).J.Med.Chem. 42 5120.
2.Laird et al (2000).Cancer Res. 60 4152.
3.Yamamoto et al (2008).Cancer Res. 68 9754.