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VD-CHR-0010-0010-10mg 80 USD
VD-CHR-0010-0050-50mg 350 USD

VU 0357017 hydrochloride

Product specification

Formula: C18H27N3O3.HCl
MW: 369.89
Purity: >=98%
Appearance: White solid.
Solubility: 25 mM in water and to 5 mM in DMSO.
Storage: +2°C to +8°C. Protect from light.
CAS Number: 1135242-13-5
Synonyms: Not available.
Cat.number: VD-CHR-0010

Product Description

Positive allosteric modulator of muscarinic M1 receptors (EC50 = 198 nM). Displays no activity at M2-M5 at concentrations up to 30 μM. Potentiates NMDA receptor currents in hippocampal neurons; activity reverses cognitive decifits in a rodent model of hippocampal-dependent memory. CNS penetrant.

Product References

1.Bridges et al (2010) Chemical lead optimization of a pan Gq mAChR M1,M3,M5 positive allosteric modulator (PAM) Lead. Part II. Development of potent and highly selective M1 PAM. Bioorg.Med.Chem.Lett. 20 1972.