Product # Price Quantity Add to cart
VD-CAN-0002-0010-10mg 100 USD
VD-CAN-0002-0050-50mg 400 USD

AM 251




Product specification

Formula: C22H21Cl2IN4O
MW: 555.24
Purity: >98 %
Appearance: White solid.
Solubility: DMSO
Storage: Store at RT.
CAS Number: 183232-66-8
Synonyms: 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-
N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide
Cat.number: VD-CAN-0002

Product Description

AM-251 is a 123I radioisotope derivative of the CB1 cannabinoid receptor inverse agonist SR141716A, presenting a radioprobe for in vivo binding studies at the CB1 receptor with a higher affinity (Ki = 7.49 nM) for CB1 than the parent compound (Ki = 11.5 nM). AM-251 has been employed in competitive binding studies to identify CB1 affinity of different cannabimimetic agonists in vivo. Characterization of AM-251-CB1 association with SPECT (single photon emission computed tomography) has been described.



Product References
1. Gatley, S.J., et al. 1997. Life Sci. 61: PL 191-PL 197.
2. Lan, R., et al. 1999. J. Med. Chem. 42: 769-776.
3. McLaughlin, P.J., et al. 2003. Behav Pharmacol. 14: 583-588.
4. Fong, T.M. and Heymsfield, S.B. 2009. Int J Obes. 33: 947-955.