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VD-AIH-0287-0005-5mg 140 USD
VD-AIH-0287-0025-25mg 550 USD

OSI 906




Product specification

Formula: C26H23N5O
MW: 421.19
Purity: >=98%
Appearance: Not available.
Solubility: DMSO.
Storage: -20°C.Protect from light.
CAS Number: 867160-71-2
Synonyms: Linsitinib
Cat.number: VD-AIH-0287

Product Description

Linsitinib (OSI 906) is  an orally bioavailable small molecule inhibitor of the insulin-like growth factor 1 receptor (IGF-1R) with potential antineoplastic activity.  OSI-906 selectively inhibits IGF-1R, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. Overexpressed in a variety of human cancers, IGFR-1 stimulates cell proliferation, enables oncogenic transformation, and suppresses apoptosis.



Product References
1.Buck E, Mulvihill M, Iwata KK. Mt Sinai J Med. 2010 Jul-Aug;77(4):358-65.