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iCRT 14 (CAS 677331-12-3)

Product specification

Formula: C21H17N3O2S
MW: 375.44
Purity: >=99%.
Appearance: Yellow to orange.
Solubility: DMSO (75 mM).
Storage: +2°C to +8°C. Protect from light.
CAS Number: 677331-12-3
Synonyms: Not available.
Cat.number: VD-CCR-0118

Product Description

iCRT 14 (CAS 677331-12-3) is a potent inhibitor of β-catenin-responsive transcription (CRT) (IC50 = 40.3 nM in assays of Wnt pathway activity). Thought to directly influence the interaction between β-catenin and TCF4. Induces marked G0/G1 cell cycle arrest in HCT-116 and HT29 cell lines.

Product References
1. Watanabe and Dai (2011) Proc.Natl.Acad.Sci.USA 108 5929.