CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-PI-0014-0001-1mg | $50 | ||
| VD-PI-0014-0005-5mg | $200 |
γ-Secretase Inhibitor III
$50.00 – $200.00
Product Specification
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Appearance:
Off-white solid
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CAS Number:
N/A
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Cat.number:
VD-PI-0014
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Formula:
C20H30N2O4
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MW:
362.5
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Purity:
≥95%
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Solubility:
DMSO
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Storage:
-20°C. Hygrocopic
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Synonyms:
N-Benzyloxycarbonyl-Leu-leucinal; Z-LL-CHO
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Size:
1mg, 5mg
Description
γ-Secretase Inhibitor III is a cell-permeable, reversible inhibitor of γ–secretase that reduces the formation of both Aβ total (IC50 ~ 35 µM) and Aβ1-42 using Chinese hamster ovary (CHO) cultures stably transfected with Amyloid Precursor Protein-751. Reported to be nontoxic and specific for γ–secretase. Also reported to inhibit calpain (IC50 = 3 µM).
1.Auvin, S., et al. 2004. Bioorg. Med. Chem. Lett. 14, 3825.
2.Figueiredo-Pereira, M.E., et al. 1999. J. Neurochem. 72, 1417
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