CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-OEIA-1043-0001-1mg | $40 | ||
| VD-OEIA-1043-0005-5mg | $120 |
Calpain Inhibitor VI
$40.00 – $120.00
Product Specification
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Appearance:
White lyophilized solid.
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CAS Number:
190274-53-4
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Cat.number:
VD-OEIA-1043
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Formula:
C17H25FN2O4S
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MW:
372.5
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Purity:
>=95%
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Solubility:
DMSO
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Storage:
-20°C.Protect from light.
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Synonyms:
N-(4-Fluorophenylsulfonyl)-L-valyl-L-leucinal, SJA6017
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Size:
1mg, 5mg
Description
A potent, cell-permeable, reversible inhibitor of calpain (IC50 = 7.5 nM for µ-calpain and 78 nM for m-calpain). Also potently inhibits cathepsin B (IC50 = 15 nM) and L (IC50 = 1.6 nM). Reduces bFGF-induced angiogenesis in rat cornea and prevents selenite cataract formation. Reduces A23187-induced nuclear opacity and proteolysis of crystallins and α-spectrin in cultured lenses.
1.Inoue, J., et al. 2003. J. Med. Chem. 46, 868.
2.Tamada, Y., et al. 2001. Curr. Eye Res. 22, 280.
3.Mathur, P., et al. 2000. Curr. Eye Res. 21, 926.
4.Nath, R., et al. 2000. Biochem. Biophys. Res. Commun. 274, 16.
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