CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-OEIA-1019-0005-5mg | $200 | ||
| VD-OEIA-1019-0025-25mg | $650 |
Eg5 Inhibitor VI
$200.00 – $650.00
Product Specification
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Appearance:
Off-white solid.
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CAS Number:
N/A
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Cat.number:
VD-OEIA-1019
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Formula:
C13H11F3N2O2S
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MW:
316.3
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Purity:
≥97% by HPLC
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Solubility:
DMSO or EtOH.
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Storage:
+2°C to +8°C. Protect from light.
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Synonyms:
N-(4′-(Trifluoromethyl)-4-biphenyl)sulfamide, KSP Inhibitor VI
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Size:
25mg, 5mg
Description
A cell-permeable biphenylsulfamide compound that acts as a potent, reversible, and ATP-competitive inhibitor of Eg5/KSP ATPase activity (IC50 = 18 nM) with reactivity against both wild-type and the D130V mutant (Ki = 6.2 nM and 7 nM, respectively) in cell-free assays. Due to a higher ATP binding affinity of the WT enzyme, the inhibitor exhibits a much weaker antiproliferative activity against WT-expressing cells in cultures (IC50 = 5.4 and 403 nM, using HCT116 D130V and HCT116, respectively) and its in vivo antitumor efficacy has only been demonstrated in HCT116 D130V xenografed mice, but not mice with WT KSP-bearing Colo205.
1.Parrish, C.A., et al. 2007. J. Med. Chem. 50, 4939.
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