CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-HA-0112-0050-50mg | $900 | ||
| VD-HA-0112-0005-5mg | $100 |
Leflunomide 3-Isomer (CAS 61643-23-0)
$100.00 – $900.00
Product Specification
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Appearance:
Fine yellowish-white powder
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CAS Number:
61643-23-0
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Cat.number:
VD-HA-0112
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Formula:
C12H9F3N2O2
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MW:
270.21
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Purity:
≥95%
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Storage:
+4˚C
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Synonyms:
5-Methyl-N-[3-(trifluoromethyl) phenyl]-4-isoxazolecarboxamide
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Size:
50mg, 5mg
Description
Leflunomide 3-Isomer (CAS 61643-23-0) is a Leflunomide (VD-HA-0262) analogue, with potential antiinflammatory and anti-viral activity. Immunosuppressant agent. In vitro the active metabolite A77 1726 inhibits dihydroorotate dehydrogenase (Ki = 2.7 μM) and de novo pyrimidine synthesis in T-cells; blocks lymphocyte cell cycle progression and proliferation. In vivo reduces inflammation in several animal models of autoimmune disease, arthritis, asthma and graft rejection.
1. Chong, A.S., et al. 1993. Transplant. Proc. 25: 747-749.
2. Chong, A.S., et al. 1993. Transplantation. 55: 1361-1366.
3. Ju, D.W., et al. 1994. Yao Xue Xue Bao. 29: 90-94.
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