CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-OEIA-1026-0010-10mg | $140 | ||
| VD-OEIA-1026-0050-50mg | $500 |
Lomeguatrib
$140.00 – $500.00
Product Specification
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Appearance:
Off-white solid.
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CAS Number:
192441-08-0
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Cat.number:
VD-OEIA-1026
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Formula:
C10H8BrN5OS
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MW:
326.17
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Purity:
>98 %
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Solubility:
Soluble to 100 mM in DMSO
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Storage:
+4°C.
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Synonyms:
PaTrin-2; 6-[(4-Bromo-2-thienyl)methoxy]-9H-purin-2-amine
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Size:
10mg, 50mg
Description
Inhibitor of O6-methylguanine-DNA methyltransferase (MGMT); (IC50 = 0.009 μM in cell-free extracts from HeLa S3 cells); attenuates MGMT activity in vitro and in vivo. Enhances the antitumor activity of temozolomide in both human melanoma and MCF-7 xenografts.
1. Reinhard et al (2001) Monosaccharide-linked inhibitors of O6-methylguanine-DNA methyltransferase (MGMT): synthesis, molecular modeling, and structure-activity relationships. J.Med.Chem. 44 4050
2. Barvaux et al (2004) Sensitization of a human ovarian cancer cell line to temozolomide by simultaneous attenuation of the Bcl-2 antiapoptotic protein and DNA repair by O6-alkylguanine-DNA alkyltransferase. Mol.Cancer Ther. 3 1215.
3. Clemons et al (2005) O6-(4-bromothenyl)guanine reverses temozolomide resistance in human breast tumor MCF-7 cells and xenografts. Br.J.Cancer 93 1152.
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