CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-OEIA-10001-0005-5mg | $70 | ||
| VD-OEIA-10001-0025-25mg | $250 |
Phosphodiesterase 4 Inhibitor
$70.00 – $250.00
Product Specification
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Appearance:
Light yellow solid
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CAS Number:
346440-86-6
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Cat.number:
VD-OEIA-10001
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Formula:
C14H15N3O4
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MW:
289.3
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Purity:
>=97%
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Solubility:
DMSO or MeOH
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Storage:
+2°C to +4°C. Protect from light.
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Synonyms:
Ethyl 3,5-dimethyl-1-(3-nitrophenyl)-1H-pyrazole-4-carboxylate
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Size:
25mg, 5mg
Description
Pyrazole compound with a high-affinity active site binding inhibitor of phosphodiesterases IVB and IVD (IC50=33 nM and 21 nM). More potent than Rolipram (IC50=570 nM and 1.1 µM for PDEIVB and PDEIVD), respectively and greater selectivity over PDEIB, PDEIIA, PDEIIIB, PDEVA, PDEVIIB, PDEVIIIA, PDEIXA and PDEXIA (IC50>30 µM) and minimally inhibit PDEXA with an IC50 of 6.9 µM.
1.Card, G.L., et al. 2005. Nat. Biotech. 23 , 201.
2.Card, G.L., et al. 2004. Structure 12, 2233.
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