CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-OEIA-1055-0010-10mg | $150 | ||
| VD-OEIA-1055-0050-50mg | $500 |
SB 203580
$150.00 – $500.00
Product Specification
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Appearance:
Cream coloured solid.
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CAS Number:
152121-47-6
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Cat.number:
VD-OEIA-1055
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Formula:
C21H16FN3OS
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MW:
377.44
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Purity:
>=98%
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Solubility:
25 mM in DMSO and to 100 mM in 1eq. HCl.
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Storage:
+2°C to +8°C. Protect from light.
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Synonyms:
4-(4-(4-fluorophenyl)-2-(4-(methylsulfinyl)phenyl)-1H-imidazol-5-yl)pyridine
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Size:
10mg, 50mg
Description
Selective inhibitor of p38 mitogen-activated protein kinase (IC50 values are 50 and 500 nM for SAPK2a/p38 and SAPK2b/p38β2 respectively). Displays 100-500-fold selectivity over LCK, GSK-3β and PKBα. Shown to inhibit interleukin-2-induced T-cell proliferation, cyclooxygenase-1 and -2, and thromboxane synthase. Enhances clonal growth of skin epithelial progenitor cells; stimulates neural stem cell (NSC) proliferation.
1.Saklatvala et al (1996). J.Biol.Chem. 271 6586.
2.Borsch-Haubold et al (1998). J.Biol.Chem. 273 28766.
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