CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-OEIA-1021-0010-10mg | $140 | ||
| VD-OEIA-1021-0050-50mg | $650 |
SB 590885
$140.00 – $650.00
Product Specification
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Appearance:
Yellow solid.
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CAS Number:
405554-55-4
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Cat.number:
VD-OEIA-1021
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Formula:
C27H27N5O2
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MW:
453.54
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Purity:
>=98%
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Solubility:
10 mM in DMSO.
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Storage:
-20°C.Protect from light.
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Synonyms:
N/A
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Size:
10mg, 50mg
Description
Potent B-Raf inhibitor (Kd = 0.3 nM). Selective for B-Raf against 46 other kinases (Ki app values are 0.16 and 1.72 nM for B-Raf and c-Raf respectively). Decreases anchorage-independent growth of melanoma cell lines. Inhibits ERK phosphorylation and proliferation in tumor cells expressing B-RafV600E.
1.Takle et al (2006) The identification of potent and selective imidazole-based inhibitors of B-Raf kinase. Bioorg.Med.Chem.Lett. 16 378.
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