CARTProduct Variations
| Product # | Price | Quantity | |
|---|---|---|---|
| VD-CHR-0010-0010-10mg | $80 | ||
| VD-CHR-0010-0050-50mg | $350 |
VU 0357017 hydrochloride
$80.00 – $350.00
Product Specification
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Appearance:
White Solid
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CAS Number:
1135242-13-5
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Cat.number:
VD-CHR-0010
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Formula:
C18H27N3O3.HCl
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MW:
369.89
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Purity:
>=98%
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Solubility:
25 mM in water and to 5 mM in DMSO.
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Storage:
+2°C to +8°C. Protect from light.
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Synonyms:
Not available.
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Size:
10mg, 50mg
Description
Positive allosteric modulator of muscarinic M1 receptors (EC50 = 198 nM). Displays no activity at M2-M5 at concentrations up to 30 μM. Potentiates NMDA receptor currents in hippocampal neurons; activity reverses cognitive decifits in a rodent model of hippocampal-dependent memory. CNS penetrant.
1.Bridges et al (2010) Chemical lead optimization of a pan Gq mAChR M1,M3,M5 positive allosteric modulator (PAM) Lead. Part II. Development of potent and highly selective M1 PAM. Bioorg.Med.Chem.Lett. 20 1972.
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